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The process

The Sucrosomial® Iron absorption process

Iron is an essential element for the body. It promotes the formation of hemoglobin and myoglobin.

Where is dietary iron absorbed?

The human body absorbs iron in the intestine, more specifically, in the duodenum. Part of the absorbed iron binds to ferritin, a protein that constitutes the main iron deposit in cells (especially in the liver, spleen and bone marrow), while another part of iron binds to transferrin and is transported to the various tissues of the body.

How is Sucrosomial® Iron absorbed?

Like food-based iron, Sucrosomial® Iron contained in the nutritional supplements of the SiderAL® range is absorbed by the cells of the intestinal mucosa.

Sucrosomial® Iron, an essential component of the SiderAL® range of nutritional supplements, passes through the stomach environment intact and is absorbed in the intestine. Sucrosomial® Technology, an exclusive patent of PharmaNutra, also ensures great tasting iron, which is therefore easier to take even for long periods of time.

The scientific research carried out by PharmaNutra, in partnership with several Italian and foreign Universities, has shown that Sucrosomial® Iron is able to pass through the gastric acid environment intact1, thanks to the protection provided by the Sucrosomial® matrix surrounding the iron pyrophosphate, enabling a greater amount of iron to become available for intestinal absorption.

Sucrosomial® Iron is absorbed via multiple novel pathways (paracellular, and trans cellular via M cells and enterocytes) for efficient uptake, mostly as intact particles. Absorption is less reliant on the DMT1 pathway and more resistant to hepcidin upregulation, remaining effective even in inflammatory states and has a beneficial effect on the microbiome as opposed to all other forms of oral iron.2

  1. Brilli, Elisa, Alessandra Romano, Angela Fabiano, Ylenia Zambito, Francesco Di Raimondo, and Germano Tarantino. “Sucrosomial technology is able to promote ferric iron absorption: pre-clinical and clinical evidences.” Blood 128, no. 22 (2016): 3618.
  2. Gómez-Ramírez S, Brilli E, Tarantino G, Girelli D, Muñoz M. Sucrosomial® Iron: An Updated Review of Its Clinical Efficacy for the Treatment of Iron Deficiency. Pharmaceuticals (Basel). 2023 Jun 6;16(6):847. doi: 10.3390/ph16060847. PMID: 37375794; PMCID: PMC10305423.